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In the TRIUMPH-1 Phase 3 trial, participants on the 12 mg dose lost an average of 28.3% of their body weight at 80 weeks, and up to 30.3% at 104 weeks in the study extension

JAMA 325 , 765779 (2021)

Additionally, some patients may experience changes in their dietary habits when starting these medications, such as reduced appetite or altered food choices, which can further contribute to digestive issues

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This means that drawing the same number of units from a 20mg/mL vial delivers double the dose compared to a 10mg/mL vial